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ORIGINAL ARTICLES (* indicates corresponding author)

Kerns, R.T., Ravindranathan, A., Hassan, S., Cage, M.P., York, T, Sikela, J.M., Williams, R.W., and *MILES, M.F. Ethanol-responsive brain region expression networks: Implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. J. Neuroscience 2005 Mar 2; 25(9): 2255-55. [Appendix material:  Table 1 | Table 2]

*McBride, W.J, Kerns, R.T., Rodd, Z.A., Strother, W.N., Edenberg, H.J., Hashimoto, J.G., Wiren, K.M, and MILES, M.F. Alcohol effects on central nervous system gene expression in genetic animal models. Alcohol Clin Exp Res. 2005 Feb; 29(2): 167-175.

*Thibault, C., Hassan, S. and MILES, M.F. Using in vitro models for expression profiling studies on ethanol and drugs of abuse. Addiction Biology, in press (2004)

Scian, M.J., Stagliano, K.E.R., Ellis, M.A., Hassan, S., Bowman, M., MILES, M.F., Deb, S.Pl, and *Deb, S. Modulation of gene expression by tumor derived p53 mutants. Cancer Research 64:7447-7454 (2004).

*Sullivan, P.F., Neale, B., van den Oord, E.J.C.G., MILES, M.F., Neale, M.C., Bulik, C.M., Joyce, P. R., Kendler, K.S., and Straub, R.E. Candidate genes for nicotine dependence via linkage, epistasis, and bioinformatics. Amer. J. of Med. Genet. B. Neuropsychiatr. Genet. 126:23-36 (2004).

Hassan, S., Duong, B., Kim, K-S., and *MILES, M.F. Pharmacogenomic analysis of mechanisms underlying ethanol regulation of dopamine b-hydroxylase. J. Biol. Chem. 278(40):38860-9 (2003).

*Zhang, L., MILES, M.F., and Adape, K.D. A model of molecular interactions on short oligonucleotide microarrays. Nature Biotech. 21:818-821 (2003).

Kerns, R.T., Zhang, L. and *MILES, M.F. Application of the S-score algorithm for analysis of oligonucleotide microarrays, Methods. 31(4):274-81 (2003).

Elliott, R.C., MILES M.F., and *Lowenstein, D.H. Microarray Analysis of Dentate Gyrus Gene Expression Indicates Parallel Molecular Mechanisms Contribute to Development- and Epilepsy-Associated Neurogenesis and Axon Outgrowth.. J. Neurosci. 23:2218-2227 (2003).

*Hoffman, P.L., MILES, M, Edenberg, H.J., Sommer, W., Tabakoff, B., Wehner, J.M., and Lewohl, J. Gene expression in brain: a window on ethanol dependence, neuroadaptation, and preference. Alcohol Clin Exp Res. 27: 155-68 (2003).

Zhang, L., Wang, L., Ravindranathan, A. and MILES, M.F. A method for improved sensitivity and reliability in analysis of oligonucleotide array expression data. J. Mol. Biol. 317: 225-235 (2002).

Lewohl, J.M., Wang, L, MILES, M.F., Zhang, L., Dodd, P.R., and *Harris, R.A. Gene expression in human alcoholism: Microarray analysis of frontal cortex. Alcohol Clin. Exp. Res. 24: 1873-1882 (2000).

Thibault, C., Lai, C., Wilke, N., Duong, B., Olive, M.F., Rahman, S., Dong, H., Lockhart D.F. and *MILES, M.F. Expression profiling of neural cells reveals specific patterns of ethanol-responsive gene expression. Mol. Pharm. 52:1593-1600 (2000).

Wilke, N., Sganga, M.W., Gayer, G.G., Hsieh, K.-P. and *MILES, M.F. Characterization of promoter elements mediating ethanol regulation of hsc70 gene transcription. J. Pharm. Exp. Ther. 292:173-180 (2000).

Thibault, C., Wang, J.-F., Charnas, R., Mirel, D., Barhite, S., and *MILES, M.F. Cloning and characterization of the rat and human phosducin-like protein genes: structure, expression, and chromosomal location. Biochim. Biophys. Acta. 1444: 346-354 (1999).

Barhite, S., Thibault, C. and *MILES, M.F. Phosducin-like protein (PhLP), a regulator of Gbg function, interacts with the proteasomal protein SUG1. Biochim. Biophys. Acta 1402:95-101 (1998).

Thibault, C., Sganga, M. and *MILES, M.F. Interaction of phosducin-like protein (PhLP) with G-protein bg subunits. J. Biol. Chem. 272:12253-12256 (1997).

Hsieh, K.-P., Wilke, N., Harris, A., and *MILES, M.F. Interaction of ethanol with inducers of glucose-regulated stress proteins: Ethanol potentiates induction of GRP78 transcription. J. Biol. Chem. 271: 2709-2716 (1996).

McGuire, D., Barhite, S., Hollander, H., and *MILES, M.F. JC virus DNA in cerebrospinal fluid of Human Immunodeficiency Virus-infected patients: Predictive value for progressive multifocal leukoencephalopathy. Ann. Neurol. 37: 395-399 (1995).

*MILES, M.F., Wilke N., Elliott, M., Tanner, W., Shah, S. Ethanol-responsive genes in neural cells include the 78-kilodalton glucose-regulated protein (GRP78) and 94-kilodalton glucose-regulated protein (GRP94) molecular chaperones. Mol. Pharm. 46: 873-879 (1994).

*MILES, M.F., Barhite, S. Sganga, M., and Elliott, M. Phosducin-like protein: An ethanol-responsive potential modulator of guanine nucleotide-binding protein function. Proc. Natl. Acad. Sci. USA 90: 10831-10835 (1993).

*MILES, M.F., Diaz, J.E. and DeGuzman, V. Ethanol-responsive gene expression in neural cell cultures. Biochim. Biophys. Acta 1138: 268-274 (1992).

Lowenstein, D.H., Chan, P.H. and *MILES, M.F. The stress protein response in cultured neurons: Characterization and evidence for a protective role in excitotoxicity. Neuron 7: 1053-1060 (1991).

Gayer, G., Gordon, A. and *MILES, M.F. Ethanol increases tyrosine hydroxylase gene expression in N1E-115 neuroblastoma cells. J. Biol. Chem. 266: 22279-22284 (1991).

*Lowenstein, D.H., MILES, M.F., Hatam, F., and McCabe, T. Up regulation of Calbindin-D28K mRNA in the rat hippocampus following focal stimulation of the perforant path. Neuron 6: 627-633 (1991).

*MILES, M.F., Diaz, J.E. and DeGuzman, V.S. Mechanisms of neuronal adaptation to ethanol: Ethanol induces Hsc70 gene transcription in NG108-15 neuroblastoma x glioma cells. J. Biol. Chem. 266: 2409-2414 (1991).

DesGroseillers, L., Cowan, D.M., MILES, M.F. and *Scheller, R.H. Aplysia neurons express microinjected neuropeptide genes. J. Mol. Cell. Biol. 7: 2762-2771 (1987).

*Jungmann, R.A., Kelley, D.C., MILES, M.F. and Milkowsky, D. Cyclic AMP regulation of lactate dehydrogenase: Isoproterenol and N6-O2'-dibutyryl cyclic AMP increase the rate of transcription and change the stability of lactate dehydrogenase A subunit messenger RNA in rat C6 glioma cells. J. Biol. Chem. 258: 5312-5318 (1983).

MILES, M.F., Hung, P. and *Jungmann, R.A. Cyclic AMP regulation of lactate dehydrogenase: Quantitation of lactate dehydrogenase M-subunit messenger RNA in isoproterenol stimulated and N6-O2'-dibutyryl cyclic AMP-stimulated rat C6 glioma cells by hybridization analysis using a cloned cDNA probe. J. Biol. Chem. 256: 12545-12552 (1981).

Derda, D.F., MILES, M.F., Schweppe, J.S., and *Jungmann, R.A. Cyclic AMP regulation of lactate dehydrogenase: Isoproterenol and N6-O2'-dibutyryl cyclic AMP increase the levels of lactate dehydrogenase 5 isozyme and its messenger RNA in rat C6 glioma cells. J. Biol. Chem. 255: 11112-11121 (1980).

*Willis, D.B., Goorha, R., MILES, M.F. and Granoff, A. Macromolecular synthesis in cells infected by frog virus 3. J. of Virology 24: 326-342 (1977).

*Pasto, D. J. and MILES, M.F. Radical additions to alkenylidenecyclopropanes. J. Org. Chem. 41: 2068-2070 (1976).

*Pasto, D.J. and MILES, M.F. Electrophilic addition reactions of alkenylidinecyclopropanes. J. Org. Chem. 41: 425-432 (1976).


Ravindranathan, A., Wilke, N., Palmiter, R., and *MILES, M.F. Expression profiling identifies molecular correlates of altered ethanol behaviors in NPY knockout mice. Manuscript in preparation (2003).

Lipton, P., Wang, L., Iller, K., Lai, C., Shen, E., Phillips, T. Lockhart, D., Hodge, C.W., and *MILES, M.F. Expression profiling suggests mechanisms underlying increased dopamine release with cocaine sensitization. Manuscript in preparation (2003).

Rahman, S., Duong, B., Thibault, C., Hodge, C.W., and *MILES, M.F. Alteration of gene expression patterns during initiation of ethanol sensitization. Manuscript in preparation (2003).

Dunty, W.C., Duong, B., Cordel, S., Sulik, K.K., and *MILES, M.F. Gene expression profiling of apoptosis-sensitive and resistant brain regions in a mouse model for fetal alcohol syndrome. Manuscript in preparation (2003)


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